SEMINAR
Collaborative Innovation Center for life and health materials, SICCAS
中國科學院上海硅酸鹽研究所生命健康材料協同創新中心
Magnetic nanoprobes for imaging-guided cancer therapy
磁性納米探針用于影像引導的腫瘤治療
侯仰龍
北京大學工學院
時間：2020年11月13日（星期五）15:30
地點：長寧園區4號樓14樓第一會議室
歡迎廣大科研人員和研究生參加討論！
聯系人：陳航榕
Abstract:
Magnetic nanoparticles are considered to have great potential in biomedical applications due to their intrinsically peculiar magnetic, high efficiency catalytic activity and good biocompatibility. This presentation will focus on the development of magnetic nanoprobes and application in imaging-guided cancer precision therapy in our group recent years. Firstly, we try to utilize the physical properties of magnetic nanoparticles to improve the diagnosis and treatment for cancer. A novel multifunctional probe Fe5C2-ZHER2:342 was designed for magnetic resonance imaging/photoacoustic tomography-guided targeting photothermal therapy.[1] Furthermore, Fe5C2 NPs can also be a remote-controlled platform for photochemothermal cancer therapy by loading anticancer drug doxorubicin. Next we have developed a magnetic nanoprobe based on pH-sensitive Fe5C2@Fe3O4 nanoparticles for switchable magnetic resonance imaging-guided cancer therapy by reactive oxygen species. To achieve multi-modality imaging, recently, multifunctional heterostructure Au-Fe2C-ZHER2:342 were fabricated as a multifunctional nanoprobe for triple-modal magnetic resonance imaging/multispectral photoacoustic tomography/computed tomography-guided photothermal therapy. Moreover, to effectively utilize the ROS effect, we proposed magnetic nanoprobe of near-infrared light and cancer microenvironment dual responsive size-switchable DOX-ICG@Fe/FeO-PPP-FA nanocapsules with PLGA which offers fluorescence imaging/magnetic resonance imaging-guided chemotherapy, photothermal therapy and chemodynamic therapy, particularly, the degradation of PLGA matrix and Fe/FeO NPs was observed, significant phenomenon for further medical applications. In summary, it is expected that magnetic probes are promising platforms which provides imaging-guided therapy triggered from their intrinsic physical properties and the contribution of other counterparts such as targeting molecules and drugs.
報告人簡介：
侯仰龍，北京大學博雅特聘教授，皇家化學會會士（FRSC），國家重點研發計劃納米科技專項首席科學家，磁電功能材料與器件北京市重點實驗室主任。主要從事多功能磁性材料、新能源材料的控制合成及其在納米生物醫學與能源領域的應用探索研究。發展了單分散磁性納米材料的通用制備方法，探索了磁性納米顆粒在腫瘤等重大疾病的診斷與治療的應用；設計制備了若干納米結構雜化材料用于高性能的鋰電池電極等。迄今發表學術論文180余篇，引用17400余次，H因子69。申請專利14項，授權12項。2019年獲國家自然科學二等獎1項。榮獲全國創新爭先獎狀、北京茅以升青年科技獎、中國化學會-英國皇家化學會青年化學獎。曾獲國家杰出青年科學基金資助，先后入選教育部長江學者特聘教授、萬人計劃科技創新領軍人才、教育部新世紀優秀人才、全國優秀科技工作者和科睿唯安高被引科學家（2018, 2019）。在國際和各類雙邊會議上作大會或分會邀請報告50余次。正主持國家重點研發計劃，國家自然科學基金委重點項目、重大項目課題等。現任Rare Metals副主編，Advanced Science、Science China Materials等期刊編委，中國化學會理事、青年委員會主任委員等。
